Freeze Drying

When you think of drying, everyone thinks of drying, boiling, drying, spray drying, and vacuum drying, but these common drying methods have one drawback:
Normally dried products generally have the problem of shrinking the volume and hardening the texture. Most of the volatile components are lost. Some heat-sensitive substances are denatured and deactivated. Some of the substances even oxidize. Therefore, there is a large difference in the properties of the dried product compared to that before drying.
The drying method used for freeze drying is lyophilization. The lyophilization method is carried out at a temperature of 0°C or less, that is, when the product is frozen, the product is allowed to rise above 0°C only when the residual moisture content of the product is reduced later, but generally does not exceed 40°C. Under vacuum conditions, when the water vapor sublimates directly, the drug remains in the frozen ice shelf, forming a sponge-like loose porous structure, so that after drying it is almost constant in size. Before using it again, as soon as water for injection is added, it dissolves immediately.
The freeze-drying system consists of a refrigeration system, a vacuum system, a heating system, and an electrical instrument control system. The main components are drying ovens, condensers, refrigeration units, vacuum pumps, heating/cooling devices, etc. Its working principle is to freeze the items to be dried below the triple point temperature, and then vacuum the solid water (ice) in the product to directly sublimate into water vapor, remove from the items, and make the items dry. After the material is pre-treated, it is sent to a quick-freezing chamber for freezing, then sent to a drying warehouse for sublimation and dehydration, and then packaged in a post-processing workshop. The vacuum system establishes a low pressure condition for the sublimation drying chamber, the heating system provides the sublimation latent heat to the material, and the refrigeration system provides the required coldness to the cold trap and the drying chamber. The equipment adopts high-efficiency radiant heating, the material is heated evenly, adopts high-efficiency catching cold trap, and can achieve rapid defrosting; adopts high-efficiency vacuum unit and can realize oil-water separation; adopts parallel centralized refrigeration system, multi-channel on-demand cooling, working conditions Stable and energy-saving; artificial intelligence control, high control accuracy, easy operation.
The quality requirements for freeze-drying products are: constant biological activity, uniform appearance, color, full shape, firm structure, fast dissolution rate, and low residual moisture. To obtain high-quality products, we should have a more comprehensive understanding of the theory and process of freeze-drying. The freeze-drying process includes pre-freeze, sublimation and re-freezing three stages. Reasonably and effectively shortening the cycle of lyophilization has obvious economic value in industrial production.

When you think of drying, everyone thinks of drying, boiling, drying, spray drying, and vacuum drying, but these common drying methods have one drawback:
Normally dried products generally have the problem of shrinking the volume and hardening the texture. Most of the volatile components are lost. Some heat-sensitive substances are denatured and deactivated. Some of the substances even oxidize. Therefore, there is a large difference in the properties of the dried product compared to that before drying.
The drying method used for freeze drying is lyophilization. The lyophilization method is carried out at a temperature of 0°C or less, that is, when the product is frozen, the product is allowed to rise above 0°C only when the residual moisture content of the product is reduced later, but generally does not exceed 40°C. Under vacuum conditions, when the water vapor sublimates directly, the drug remains in the frozen ice shelf, forming a sponge-like loose porous structure, so that after drying it is almost constant in size. Before using it again, as soon as water for injection is added, it dissolves immediately.
The freeze-drying system consists of a refrigeration system, a vacuum system, a heating system, and an electrical instrument control system. The main components are drying ovens, condensers, refrigeration units, vacuum pumps, heating/cooling devices, etc. Its working principle is to freeze the items to be dried below the triple point temperature, and then vacuum the solid water (ice) in the product to directly sublimate into water vapor, remove from the items, and make the items dry. After the material is pre-treated, it is sent to a quick-freezing chamber for freezing, then sent to a drying warehouse for sublimation and dehydration, and then packaged in a post-processing workshop. The vacuum system establishes a low pressure condition for the sublimation drying chamber, the heating system provides the sublimation latent heat to the material, and the refrigeration system provides the required coldness to the cold trap and the drying chamber. The equipment adopts high-efficiency radiant heating, the material is heated evenly, adopts high-efficiency catching cold trap, and can achieve rapid defrosting; adopts high-efficiency vacuum unit and can realize oil-water separation; adopts parallel centralized refrigeration system, multi-channel on-demand cooling, working conditions Stable and energy-saving; artificial intelligence control, high control accuracy, easy operation.
The quality requirements for freeze-drying products are: constant biological activity, uniform appearance, color, full shape, firm structure, fast dissolution rate, and low residual moisture. To obtain high-quality products, we should have a more comprehensive understanding of the theory and process of freeze-drying. The freeze-drying process includes pre-freeze, sublimation and re-freezing three stages. Reasonably and effectively shortening the cycle of lyophilization has obvious economic value in industrial production.